Gregory Basura, M.D., Ph.D.
- Asst. Professor, Department of Otolaryngology-Head & Neck Surgery
- Research Faculty Affiliate, CHGD
University of Michigan Medical Center
1500 E. Medical Center Drive, SPC5312
Ann Arbor, MI 48109-0312
As a clinician-neuroscientist, Dr. Basura’s current research interests involve both basic science inquiry and clinical translational application. At the basic science level, he is currently investigating the role of multi-sensory integration in the modulation of central auditory pathways in both normal and in aberrant conditions of noise damage and tinnitus, using a guinea pig model of noise-induced tinnitus and in vivo electrophysiology recordings to specifically understand how non-auditory systems modulate firing properties in auditory cortex neurons. The goal of this basic science component is to elucidate the neural origins of tinnitus percepts and their modulation by non-auditory pathways through multi-sensory integration. This research also seeks to identify anatomic and cellular localization of neurotransmitter receptors (i.e., acetylcholine) that may be potential pharmacologic targets or modulators to regulate pathologic neural activity linked to tinnitus generation. With training as both a basic neuroscientist and as a clinician/surgeon, Dr. Basura is in an ideal position to investigate disease processes like tinnitus and auditory aberrancy from a fundamental basic science perspective while maintaining the clinical opportunity to extrapolate investigate inquiry to the human condition.